Perioperative medicine & outcomes
Complications of Factor V Leiden in Adults Undergoing Noncardiac Surgical Procedures: A Systematic Review
Authors' conclusion
Factor V Leiden status may confer additional risk for surgery-related adverse outcomes.
Study context
- Population
- Adults (>18 years) undergoing noncardiac surgery; pediatric and obstetrical patients excluded32 studies
- Comparison
- Factor V Leiden vs no diagnosis of hereditary thrombophilia
- Outcome
- Thromboembolic events:
- DVT
- PE
- Other clinically significant thrombosis during or after surgery
- Follow-up
- Perioperative period up to 1 year postoperatively
Methodological detailsfocused systematic review, randomised and observational studies, no meta-analysis (high heterogeneity), MEDLINE and EMBASE searched from inception until August 2021, Bias assessed with CLARITY Risk of Bias tools, High heterogeneity precluded meta-analysis, 5275 potentially relevant studies identified, 115 full texts assessed, 32 included
- Focused systematic review
- Randomised and observational studies
- No meta-analysis (high heterogeneity)
- MEDLINE and EMBASE searched from inception until August 2021
- Bias assessed with CLARITY Risk of Bias tools
- High heterogeneity precluded meta-analysis
- 5275 potentially relevant studies identified, 115 full texts assessed, 32 included
Pooled result
As reported in the abstract
Perioperative and postoperative thromboembolic events
- Increased risk with Factor V Leiden vs patients without the diagnosis
Further pooled results
Surgery-specific morbidity and transplant-related outcomes
- Increased risk, particularly arterial thrombotic events
Mortality, cerebrovascular and cardiac complications
- No increased risk supported
Original publication
Complications of Factor V Leiden in Adults Undergoing Noncardiac Surgical Procedures: A Systematic Review. Anesth Analg. Published 17 August 2023. doi:10.
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