Respiratory failure & ventilation
Composition and diversity of the pulmonary microbiome in acute respiratory distress syndrome: a systematic review
Authors' conclusion
The relationship between the pulmonary microbiome and clinical outcomes, remains an area of active investigation.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS)
- Participants
- 660 patients · 11 studies
- Outcome
- Composition of the lung microbiome in ARDS
Pooled result
As reported in the abstract
Lung microbiome composition
- Different but consistent changes in microbial composition across studies
- Trend to increased prevalence of specific opportunistic pathogens, particularly gut-associated Enterobacteriaceae
- Differences in populations, methods and sequencing techniques influenced results
Further pooled results
Microbial diversity
- Findings on diversity varied across studies
Enterobacteriaceae and clinical outcomes
- Enterobacteriaceae associated with fewer ventilator-free days and mortality
Original publication
Composition and diversity of the pulmonary microbiome in acute respiratory distress syndrome: a systematic review. Crit Care. Published 18 August 2025. doi:10.
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