ICU sedation, delirium & recovery
Comprehensive assessment and progression of health status during neurorehabilitation in survivors of critical illness: a prospective cohort study
Authors' conclusion
Despite significant improvements during rehabilitation, survivors after critical illness experience a substantial burden of PICS and ICUAW at discharge from rehabilitation care.
Study context
- Population
- Critical illness survivors with ≥ 5 days of mechanical ventilation on the intensive care unit (ICU) admitted to neurorehabilitation
- Participants
- 250 survivors
- Outcome
- Prevalence of PICS (≥1 impairment in any PICS dimension)
- Follow-up
- V1 (after ICU discharge) and V2 (before discharge from neurorehabilitation)
Main finding
As reported in the abstract
- Post-intensive care syndrome (PICS) at V1
- 96%
- PICS at V2
- 85%
- Physical domain (ICUAW, MRC sum score < 48) at V1
- 87%
- Physical domain (ICUAW, MRC sum score < 48) at V2
- 66%
- Cognitive domain (Montreal Cognitive Assessment < 26) at V1
- 65%
- Cognitive domain (Montreal Cognitive Assessment < 26) at V2
- 55%
- Mental impairment (Hospital Anxiety and Depression Scale > 7) at V1
- 48%
- Mental impairment (Hospital Anxiety and Depression Scale > 7) at V2
- 29%
Observational data: associations, not effects.
Further findings
Change in outcomes during rehabilitation
- All outcomes improved significantly except sensory impairment and pain
Health-related quality of life (EQ-5D-5L index value) · discharge
- EQ-5D-5L index value, mean ± SD
- 0.64 ± 0.28
Factors associated with poor rehabilitation outcome (modified Rankin Scale > 2)
- MRC sum score at V1, duration of mechanical ventilation and female gender significantly associated
Factors associated with persistent ICUAW at discharge
- Grip strength in % of reference at V1, age, female gender and comorbidities significantly associated
Death before V2
- Died before V2
- 11 (4.4%)
Original publication
Comprehensive assessment and progression of health status during neurorehabilitation in survivors of critical illness: a prospective cohort study. Ann Intensive Care. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →