Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation
An erratum to this article was published (Intensive Care Med, Dec 2024 ↗)
Primary result · ICU-free days to day 28Result — go to the resultMedian treatment effect 0 days 95% CI - 3.1 to 3.1Authors' conclusion
In adults receiving VA-ECMO in ICU, a conservative compared to a liberal oxygen strategy, did not affect the number of ICU-free days to day 28.
Study context
- Population
- Adults receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) in an intensive care unit (ICU) (cardiogenic shock or refractory cardiac arrest)192 cardiogenic shock, 108 refractory cardiac arrest
- Participants
- 300 adults
- Comparison
- Conservative vs liberal oxygen strategy
- Conservativen = 149
- Liberaln = 151reference
- Primary endpoint
- ICU-free days to day 28
- Follow-up
- Day 28
Methodological detailsregistry-embedded, multicentre
- Registry-embedded
- Multicentre
Primary result
As reported in the abstract
Median treatment effect
0 days
95% CI - 3.1 to 3.1
By group
Conservative
0
median · IQR 0–13.7 · days
Liberal
0
median · IQR 0–13.7 · days
Secondary outcomes
Mortality · day 28
Denominator as printed Conservative 159
Denominator Liberal 151
Mortality · day 60
Major protocol deviations
P < 0.001
Mortality · day 28
- Similar in conservative and liberal groups
Mortality · day 60
- Similar in conservative and liberal groups
All other secondary outcomes (ICU-free days to day 60, ECMO and ventilation duration, ICU and hospital LOS, functional outcomes at 6 months)
- Similar in conservative and liberal groups
Safety
Adverse events
- Similar in conservative and liberal groups
Original publication
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