Impact of Conservative Vs. Liberal Extracorporeal Oxygen Target During Venoarterial Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock: A Pilot Randomized Control Trial
Authors' conclusion
In patients supported by VA ECMO for cardiogenic shock, a conservative oxygen target strategy was not easily feasible, as P POST O 2 could be maintained within the targeted window only 33% of time.
Study context
- Population
- Cardiogenic shock supported by VA ECMO; 4 ICUs in 3 teaching hospitals, eastern France55 analysed
- Comparison
- Conservative vs liberal extracorporeal oxygen target
- Primary endpoint
- Plasma intestinal fatty acid binding protein (IFABP) level, a marker of gut damage
- Follow-up
- Day 2
Methodological detailspilot, multicentre
- Pilot
- Multicentre
Primary result
As reported in the abstract
IFABP
P = 0.25
Secondary outcomes
| Outcome | Values |
|---|---|
| FDO2 (arm separation) · first 7 days | Conservative 61 ± 7 % · Liberal 98 ± 5 % |
| PPOSTO2 (arm separation) · first 7 days | Conservative 139 ± 40 mm Hg · Liberal 420 ± 50 mm Hg |
| Feasibility: proportion of time within targeted window | Conservative mean 33 ± 20 % |
Lactate, vasoactive inotropic score, AST, prothrombin time, serum creatinine, need for RRT, TNF-α, IL-6, IL-8 · day 0, 2, and 6
- Did not differ between the two arms
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of Conservative Vs. Liberal Extracorporeal Oxygen Target During Venoarterial Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock: A Pilot Randomized Control Trial. Crit Care Med. Published 23 September 2025. doi:10.
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