Respiratory failure & ventilation
Conservative versus liberal oxygen therapy for intensive care unit patients: meta-analysis of randomized controlled trials
Authors' conclusion
COT did not reduce all-cause mortality in ICU patients.
Study context
- Population
- Intensive care unit (ICU) patients
- Participants
- 10,632 patients · 13 randomized controlled trials (RCTs)
- Comparison
- Conservative vs liberal oxygen therapy
- Outcome
- Mortality rate
Pooled result
As reported in the abstract
Mortality
COT vs LOTRelative risk (95% CI)P value
30-day; I2 = 42%
1.01(0.94–1.09)
P = 0.7890-day; I2 = 9%
1.01(0.95–1.08)
P = 0.69Longest follow-up; I2 = 22%
1.00(0.95–1.06)
P = 0.95Further pooled results
Mortality by ICU type, baseline P/F and actual PaO2 (subgroup)
- No significant difference between the two groups
ICU LOS, hospital LOS, vasopressor-free time (VFT)
- Not affected by conservative oxygen therapy (COT)
Days free from mechanical ventilation support (MVF)
- Affected by COT
Original publication
Conservative versus liberal oxygen therapy for intensive care unit patients: meta-analysis of randomized controlled trials. Ann Intensive Care. Published 26 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →