Contamination of Blood Cultures From Arterial Catheters and Peripheral Venipuncture in Critically Ill Patients: A Prospective Multicenter Diagnostic Study
Performance · Contamination proportionResult — go to the resultDifference −0.3% one-sided 95% CI upper limit +0.3%Authors' conclusion
Obtaining blood cultures from arterial catheters is an acceptable alternative to venipuncture in critically ill patients.
Study context
- Population
- Critically ill adults with suspected bloodstream infection and clinical indication for blood cultures, 5 hospitals
- Participants
- 590 paired blood culture episodes
- Comparison
- Blood cultures from arterial catheters vs peripheral venipuncture
- Arterial cathetern = 590
- Venipuncturen = 590reference
- Outcome
- Proportion of contamination (number of false-positive results relative to total number of procedures done)
Methodological detailsmulticentre, prospective, paired, non-inferiority, December 2018 to July 2021; 1,655 blood culture episodes screened
- Multicentre
- Prospective
- Paired
- Non-inferiority
- December 2018 to July 2021; 1,655 blood culture episodes screened
Performance
Contamination proportion
Difference
−0.3%
one-sided 95% CI upper limit +0.3%
P < 0.001 for non-inferiority
Events by group
Arterial catheter vs Venipuncture
difference −0.3% (one-sided 95% CI upper limit +0.3%); P for non-inferiority < 0.001
As reported in the abstract
Further findings
Positive blood cultures
True bloodstream infection (episodes)
- Episodes with true bloodstream infection
- 41 of 590 (6.9%)
Original publication
Contamination of Blood Cultures From Arterial Catheters and Peripheral Venipuncture in Critically Ill Patients: A Prospective Multicenter Diagnostic Study. Chest. Published 30 January 2023. doi:10.
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