Usefulness of differential time to positivity between catheter and peripheral blood cultures for diagnosing catheter-related bloodstream infection: Data analysis from routine clinical practice in the intensive care unit
Authors' conclusion
The routine use of the DTP method at any cutoff point has inadequate accuracy in detecting CRBSI in the real every day clinical practice. Not even the ratio between times to positivity seems to be clinically useful.
Study context
- Population
- Intensive care unit (ICU) patients with a central venous catheter in place ≥48 h undergoing differential time to positivity (DTP) test with catheter tip culture, over a five-year periodepisodes of paired blood cultures
- Participants
- 278 patients
- Comparison
- DTP test vs catheter tip culture for catheter-related bloodstream infections (CRBSI)
- Outcome
- Accuracy of DTP for diagnosis of CRBSI
Methodological detailssingle-centre, routine clinical practice data
- Single-centre
- Routine clinical practice data
Performance
As reported in the abstract
Diagnostic accuracy for CRBSI
| Test or model | AUC | Sensitivity | Specificity |
|---|---|---|---|
| DTP ≥120 min | — not stated in the abstract | 41% | 74% |
| DTP (all values) | 0.60 [95%CI: 0.48-0.72] | — not stated in the abstract | — not stated in the abstract |
| Ratio 0.80 | — not stated in the abstract | 46% | 79% |
AUC
DTP ≥120 min— not stated in the abstract
DTP (all values)0.60 [95%CI: 0.48-0.72]
Ratio 0.80— not stated in the abstract
Sensitivity
DTP ≥120 min41%
DTP (all values)— not stated in the abstract
Ratio 0.8046%
Specificity
DTP ≥120 min74%
DTP (all values)— not stated in the abstract
Ratio 0.8079%
— not stated in the abstract
Further findings
CRBSI prevalence among episodes
- CRBSIs among paired blood culture episodes
- 13%
Original publication
Usefulness of differential time to positivity between catheter and peripheral blood cultures for diagnosing catheter-related bloodstream infection: Data analysis from routine clinical practice in the intensive care unit. J Crit Care. Published 25 January 2023. doi:10.
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