Time to positivity as a predictor of catheter-related bacteremia and mortality in adults with Pseudomonas aeruginosa bloodstream infection
Authors' conclusion
Moreover, lower TTP have also prognostic implications in both catheter-related and non-catheter-related infections.
Study context
- Population
- Adults with Pseudomonas aeruginosa bloodstream infection (Pseudomonas aeruginosa BSI (PAE-BSI))
- Participants
- 1,177 PAE-BSI cases
- Exposure
- Time to positivity (TTP) and DTP for identifying catheter-related PAE-BSI; TTP and 30-day mortality
- Outcome
- Diagnostic utility and best cut-off values of TTP and DTP to identify catheter-related PAE-BSI; association of TTP with 30-day mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Factors independently associated with catheter-related PAE-BSI
- Breakthrough bacteremia regardless of TTP, >1 positive blood culture or >7 days with a catheter in place, and both TTP <13h and DTP >2h independently associated with catheter-related PAE-BSI
Observational data: associations, not effects.
Further findings
- Catheter-related: TTP <14h with catheter not removed within 48h, OR
- 2.9[1.04-8] (CI)
- Other sources: TTP <16h, OR
- 1.6[1.1-2.4] (CI)
- Other sources: TTP <16h with non-active empiric antibiotic therapy, OR
- 3.8[1.5-10] (CI)
- Lower TTP significantly associated with higher 30-day mortality in both catheter-related and non-catheter-related PAE-BSI
Original publication
Time to positivity as a predictor of catheter-related bacteremia and mortality in adults with Pseudomonas aeruginosa bloodstream infection. Crit Care. Published 6 February 2025. doi:10.
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