Perioperative medicine & outcomes
Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial
Authors' conclusion
Giving norepinephrine continuously during induction of general anaesthesia, compared with giving it as repeated manual boluses, improved blood pressure stability in higher-risk individuals undergoing noncardiac surgery.
Study context
- Population
- High-risk patients undergoing noncardiac surgery under GA, arterial catheter monitoring71 completed
- Participants
- 72 patients
- Comparison
- Continuous vs Manual bolus
- Continuousn = 36
- Manual bolusn = 35reference
- Primary endpoint
- BP stability: generalised average real variability of MAP
- Follow-up
- Within 15 min after starting induction of GA
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
P < 0.001
Original publication
Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial. Br J Anaesth. Published 30 July 2025. doi:10.
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