Continuous renal replacement therapy and survival in acute liver failure: A systematic review and meta-analysis
Pooled result · Overall survivalResult — go to the resultRR, event not clear from abstract 0.83 95% CI 0.70–0.99Authors' conclusion
Use of CRRT in ALF patients is associated with improved overall and transplant-free survival compared to no CRRT.
Study context
- Population
- Adults admitted to an ICU with acute liver failure (ALF)
- Participants
- 305 vs 1,137
- Comparison
- Continuous renal replacement therapy (CRRT) vs standard care without CRRT
- CRRTn = 305
- No CRRTn = 1,137reference
- Outcome
- Overall survival
Pooled result
As reported in the abstract
RR, event not clear from abstract
0.83
95% CI 0.70–0.99
p-value 0.04
CRRT vs No CRRT
RR, event not clear from abstract 0.83 (95% CI 0.70–0.99); p-value 0.04
Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| Transplant-free survival (TFS)I2 = 25% | RR, event not clear from abstract 0.65 (95% CI 0.49–0.85) | p-value 0.002 | |
| MortalityI2 = 37% · trend towards higher mortality with no CRRT | RR for mortality 1.24 (95% CI 0.84–1.81) | p-value 0.28 | |
| 0.512Ratio (log scale) |
Transplant-free survival (TFS)
- CRRT associated with improved TFS
Serum ammonia clearance
- Ammonia clearance data could not be pooled and was not analysable
Original publication
Continuous renal replacement therapy and survival in acute liver failure: A systematic review and meta-analysis. J Crit Care. Published 9 January 2024. doi:10.
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