Contribution of Acute Kidney Injury After Liver Transplant in Development of Chronic Kidney Disease: A Single-Center Retrospective Cohort Study
Authors' conclusion
Severe postoperative AKI is associated with an increased risk of severe CKD at 1 year and mortality up to 3 years after liver transplant.
Study context
- Population
- Liver transplant recipients
- Participants
- 1,574 recipients
- Exposure
- Severe acute kidney injury (AKI) vs no severe AKI within 72 hours postoperatively
- Severe AKIn = 769
- Outcome
- Severe CKD (eGFR <30 mL/min/1.73 m 2)
- Follow-up
- Year 1
Methodological detailssingle-centre, discrete-time targeted maximum likelihood estimation
- Single-centre
- Discrete-time targeted maximum likelihood estimation
Main finding
As reported in the abstract
Severe CKD
Each group vs no severe AKIEstimate (95% CI)
Severe AKI
adjusted RR 2.62(1.61–4.28)
Severe AKI
unadjusted RR 3.66(2.15–7.33)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Death · year 1Severe AKI vs No severe AKI | adjusted RR 1.15 (95% CI 1.04–1.28) | |
| Death · year 1Severe AKI vs No severe AKI | unadjusted RR 2.41 (95% CI 1.47–4.19) | |
| Death · year 2Severe AKI vs No severe AKI | adjusted RR 1.14 (95% CI 1.04–1.25) | |
| Death · year 2Severe AKI vs No severe AKI | unadjusted RR 1.51 (95% CI 1.07–2.19) | |
| Death · year 3Severe AKI vs No severe AKI | adjusted RR 1.13 (95% CI 1.04–1.23) | |
| Death · year 3Severe AKI vs No severe AKI | unadjusted RR 1.44 (95% CI 1.05–1.97) | |
| 0.20.5125Ratio (log scale) |
Chronic kidney disease (CKD) stage at year 1 (all patients)
- Normal/mild
- 1024 (65%)
- Moderate CKD
- 487 (31%)
- Severe CKD
- 63 (4%)
Deaths (all patients) · years 1, 2 and 3
- Year 1
- 66 (4%)
- Year 2
- 115 (7%)
- Year 3
- 147 (9%)
Original publication
Contribution of Acute Kidney Injury After Liver Transplant in Development of Chronic Kidney Disease: A Single-Center Retrospective Cohort Study. Anesth Analg. Published 26 January 2026. doi:10.
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