Correction of Trauma-induced Coagulopathy by Goal-directed Therapy: A Secondary Analysis of the Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy (ITACTIC) Trial
Authors' conclusion
In ITACTIC, many bleeding trauma patients did not receive an indicated goal-directed treatment. Interventions arrived late during resuscitation and were only partially effective at correcting coagulopathy.
Study context
- Population
- Bleeding trauma patients in ITACTIC with full viscoelastic and conventional coagulation test results
- Participants
- 133 patients
- Comparison
- Viscoelastic vs Standard
- Primary endpoint
- Correction of coagulopathy (EXTEM A5 <40 mm) by the 12th unit of RBC transfusion during resuscitation
Methodological detailssubgroup coenrolled in a prospective observational study, two sites
- Subgroup coenrolled in a prospective observational study
- Two sites
Primary result
As reported in the abstract
Correction of coagulopathy
Corrected coagulopathy with goal-directed treatment
20%
Corrected coagulopathy with empiric treatment alone (not significant)
0%
Further findings
| Outcome | Viscoelastic | Standard | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Receipt of goal-directed treatment | 76% | 47% | 3.73 (1.64–8.49) | P = 0.002 | |
| 0.10.31310Odds ratio (log scale) |
Time to first goal-directed treatment
P = 0.005
- Receipt of goal-directed treatment — Received goal-directed treatment, overall
- 54%
Coagulopathy
- Coagulopathic on admission
- 71%
- Developed coagulopathy during resuscitation
- 16%
Original publication
Correction of Trauma-induced Coagulopathy by Goal-directed Therapy: A Secondary Analysis of the ITACTIC Trial. Anesthesiology. Published 8 August 2024. doi:10.
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