Viscoelastic coagulation testing in bleeding trauma patients: a retrospective analysis and development of a treatment algorithm
Authors' conclusion
These ClotPro® cut-off values allow for early and reliable detection of hypofibrinogenaemia and thrombocytopenia.
Study context
- Population
- Bleeding trauma patients, on arrival, during surgery and in ICU67.8% male
- Participants
- 375 patients
- Comparison
- ClotPro® viscoelastic parameters vs standard coagulation tests
- Outcome
- Detection of coagulation deficits (ROC analysis)
Methodological detailsTreatment algorithm for early treatment of trauma-induced coagulopathy developed from these data
- Treatment algorithm for early treatment of trauma-induced coagulopathy developed from these data
Performance
As reported in the abstract
| Test or model | AUC (INR >1.2) | AUC (fibrinogen <150 mg dl-1) | AUC (platelets <50 G L-1) | AUC (platelets <100 G L-1) |
|---|---|---|---|---|
| EX-Test CT | 0.71 | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract |
| FIB-Test CA5 | — not stated in the abstract | 0.96 | — not stated in the abstract | — not stated in the abstract |
| CA5-derived platelet contribution | — not stated in the abstract | — not stated in the abstract | 0.93 | 0.94 |
AUC (INR >1.2)
EX-Test CT0.71
FIB-Test CA5— not stated in the abstract
CA5-derived platelet contribution— not stated in the abstract
AUC (fibrinogen <150 mg dl-1)
EX-Test CT— not stated in the abstract
FIB-Test CA50.96
CA5-derived platelet contribution— not stated in the abstract
AUC (platelets <50 G L-1)
EX-Test CT— not stated in the abstract
FIB-Test CA5— not stated in the abstract
CA5-derived platelet contribution0.93
AUC (platelets <100 G L-1)
EX-Test CT— not stated in the abstract
FIB-Test CA5— not stated in the abstract
CA5-derived platelet contribution0.94
— not stated in the abstract
Original publication
Viscoelastic coagulation testing in bleeding trauma patients: a retrospective analysis and development of a treatment algorithm. Br J Anaesth. Published 7 November 2025. doi:10.
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