Thromboelastometry-guided haemostatic resuscitation in severely injured patients: a propensity score-matched study
Authors' conclusion
A VHA-based strategy was associated with an increase of the number of patients alive and free of MT at 24 h together with an important reduction of blood product use and associated costs. However, that did not translate into an improvement in mortality.
Study context
- Population
- Injured patients receiving at least 1 unit of RBC in the first 24 h after admission, 2 trauma centres, 2012–2019215 per group after matching
- Participants
- 624 patients
- Exposure
- Viscoelastic haemostatic assays (VHA)-based vs conventional coagulation test (CCT)-based algorithm for managing TIC
- VHAn = 215
- CCTn = 215reference
- Outcome
- Proportion alive and free of massive transfusion (MT)
- Follow-up
- 24 h after injury
Methodological detailspropensity-score matched, 2 trauma centres, registry-based
- Propensity-score matched
- 2 trauma centres
- Registry-based
Main finding
As reported in the abstract
24 h
P < 0.01
Observational data: associations, not effects.
Further findings
Massive transfusion · 24 h · propensity score-matched
P < 0.01
Overall cost of blood products and coagulation factors
P < 0.001
Mortality · 24 h
- No significant difference in mortality at 24 h
- OR 0.94 (0.59-1.51) (95% CI)
Survival · day 28
- No significant difference in survival at day 28
- OR 0.87 (0.58-1.29) (95% CI)
Original publication
Thromboelastometry-guided haemostatic resuscitation in severely injured patients: a propensity score-matched study. Crit Care. Published 13 April 2023. doi:10.
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