Respiratory failure & ventilation
Covid-19-associated pulmonary aspergillosis in mechanically ventilated patients: incidence and outcome in a French multicenter observational cohort (APICOVID)
Authors' conclusion
Probable CAPA is a rare but serious complication of severe COVID-19 requiring mechanical ventilation and is associated with higher day-90 mortality.
Study context
- Population
- Consecutive adults admitted to 15 French intensive care units (ICUs) in 2020 for COVID-19 requiring mechanical ventilation
- Participants
- 708 adults · 15 French ICUs
- Outcome
- Incidence of proven/probable CAPA
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
Proven/probable CAPA
Probable CAPA
18
2.5%
Histologically proven CAPA
0
Observational data: associations, not effects.
Secondary outcomes
Risk factors for probable CAPA: older age (only significant factor)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Older age | 1.04 (1.00–1.09) | P = 0.04 | |
| 0.512Hazard ratio (log scale) |
Day-90 mortality, probable CAPA
| HR (95% CI) | P value | ||
|---|---|---|---|
| Probable CAPA | 2.07 (1.32–3.25) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Mechanical ventilation duration and ICU LOS, probable CAPA
- Probable CAPA not associated with longer mechanical ventilation or ICU LOS
Original publication
Covid-19-associated pulmonary aspergillosis in mechanically ventilated patients: incidence and outcome in a French multicenter observational cohort (APICOVID). Ann Intensive Care. Published 29 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →