COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation
Authors' conclusion
Elevated neutrophil-to-lymphocyte ratio is a prognostic indicator of COVID-19 bacterial co-infection within 48-h of admission. Community-acquired bacterial co-infection, as defined by blood culture-positive results, confers greater increased risk of in-hospital mortality, ICU admission, and mechanical ventilation than previously described risk factors (advanced age, select comorbidities, male sex) for COVID-19 mortality, and is independent of SARS-CoV-2 variant.
Study context
- Population
- COVID-19 inpatient encounters, 2020–2022, UAB and OLHS cohorts13,781 COVID-19 + 99,170 pre-COVID encounters
- Exposure
- Confirmed vs suspected vs no community-acquired bacteremic co-infection in COVID-19 inpatients
- UAB pre-COVID-19 pandemicn = 99,170
- Outcome
- In-hospital mortality, ICU admission and mechanical ventilation
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Risk factor for COVID-19 bacterial co-infection: elevated ≥ 15 neutrophil-to-lymphocyte ratio within 48-h of admission · within 48-h of hospital admission
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Elevated ≥ 15 neutrophil-to-lymphocyte ratioUAB cohort · multivariate logistic regression | 1.95 (1.21–3.07) | P < 0.001 | |
| Elevated ≥ 15 neutrophil-to-lymphocyte ratioOLHS cohort · multivariate logistic regression | 3.65 (2.66–5.05) | P < 0.001 | |
| 0.20.5125Adjusted odds ratio (log scale) |
In-hospital mortality, COVID-19 bacterial co-infection vs community-acquired bacteremia pre-COVID-19 pandemic
- Consistent across alpha, delta, and omicron SARS-CoV-2 variants
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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