ICU sedation, delirium & recovery
Creatinine production rate is an integrative indicator to monitor muscle status in critically ill patients
Authors' conclusion
CPR represents an integrative indicator of skeletal muscle status in critically ill patients, reflecting both quantitative and qualitative aspects.
Study context
- Population
- Critically ill ICU patients (plus animal models of systemic inflammation)ICU survival cohort
- Participants
- 629 patients
- Outcome
- Determinants and clinical utility of creatinine production rate (CPR)
Methodological detailsanimal experiments, clinical cohort
- Animal experiments
- Clinical cohort
Main finding
As reported in the abstract
Lower baseline creatinine production rate (CPR) index independently associated with higher 1-year mortality (HR per 0.1 g/day/m² less)
HR 1.125
P < .001
Decrease in CPR over first 3 days independently associated with higher 1-year mortality (HR per 5%)
HR 1.028
P = 0.032
Original publication
Creatinine production rate is an integrative indicator to monitor muscle status in critically ill patients. Crit Care. Published 14 January 2025. doi:10.
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