ICU sedation, delirium & recovery
Identifying distinct clusters of ICU survivors by integrating demographic, pre-admission quality of life, and clinical data: a large prospective cohort study
Authors' conclusion
This study identified and externally validated four distinct clusters of ICU patients by integrating both clinical and non-clinical data.
Study context
- Population
- Adult ICU survivors of six hospitals (MONITOR-IC cohort)
- Participants
- 2,361 survivors · 6 hospitals
- Exposure
- Clusters of ICU survivors identified by demographic, pre-admission quality of life and clinical data
- Cluster-An = 204
- Cluster-Bn = 877
- Cluster-Cn = 632
- Cluster-Dn = 648
- Outcome
- Self-reported physical, mental and cognitive functioning, and quality of life
- Follow-up
- One year post-ICU
Methodological detailscluster analysis (k-prototypes algorithm), multicentre, external validation
- Cluster analysis (k-prototypes algorithm)
- Multicentre
- External validation
Main finding
As reported in the abstract
Long-term physical, mental and cognitive functioning, and quality of life
- The four clusters differed significantly in long-term physical, mental and cognitive functioning, and quality of life
- Cluster-A: relatively high quality of life at one year, despite a mean decline from baseline
- Cluster-B: best outcomes
- Cluster-C: moderate impairments both pre- and one-year post-ICU
- Cluster-D: impaired outcomes one year post-ICU, although improved compared to pre-admission status
Observational data: associations, not effects.
Further findings
External validation (five additional hospitals, n = 866)
- External validation confirmed the generalizability of these results
Original publication
Identifying distinct clusters of ICU survivors by integrating demographic, pre-admission quality of life, and clinical data: a large prospective cohort study. Intensive Care Med. Published 7 August 2025. doi:10.
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