ICU sedation, delirium & recovery
Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study
Authors' conclusion
This study reports on the potential of the IPP gene set to identify ICU patients presenting with mHLA-DR less than 8,000 AB/C.
Study context
- Population
- Critically ill adults with various etiologies in an ICU, University Hospital, Lyon, France (REALISM study), and healthy volunteers1,731 blood samples
- Exposure
- IPP gene set vs mHLA-DR for identifying immunosuppression
- Outcome
- Identification of immunosuppressed patients
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
| Group | AUC |
|---|---|
| IPP | 0.86 (95% CI 0.83-0.89) |
IPP
AUC0.86 (95% CI 0.83-0.89)
Observational data: associations, not effects.
Further findings
- ICU-acquired infections in the immunosuppressed group (patients still in ICU at days 5-7) · days 5-7 after admission — IPP
- 26%
- ICU-acquired infections in the immunosuppressed group (patients still in ICU at days 5-7): mHLA-DR 22%
- ICU-acquired infections in the immunosuppressed group (patients still in ICU at days 5-7): 123 patients still in the ICU
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study. Crit Care Med. Published 14 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →