Identification of a sub-group of critically ill patients with high risk of intensive care unit-acquired infections and poor clinical course using a transcriptomic score
Authors' conclusion
The transcriptomic score provides a useful and reliable companion diagnostic tool to further develop immune modulating drugs in sepsis in the context of personalized medicine.
Study context
- Population
- Critically ill patients of various etiologies still in intensive care unit (ICU) at day 5–7 (training); septic patients (validation)training cohort
- Participants
- 176 patients
- Comparison
- Transcriptomic score (TScore) high-risk vs low-risk group
- Outcome
- ICU-acquired infections (ICU-AI) after day 5-7
Methodological detailsprospective training cohort (REALISM study), retrospective validation cohort, prototype multiplex PCR
- Prospective training cohort (REALISM study)
- Retrospective validation cohort
- Prototype multiplex PCR
Performance
As reported in the abstract
ICU-AI, training cohort
- High-risk group share of patients
- 49%
Further findings
ICU LOS, training cohort
P < 0.001
ICU mortality, training cohort
ICU-AI, validation cohort (257 septic patients)
P = 0.06
- ICU-acquired infections (ICU-AI), validation cohort (257 septic patients) — High-risk patients identified in validation cohort
- 62%
- ICU-AI, validation cohort (257 septic patients): 160 = high-risk patients (n), not ICU-AI events
Immune suppression features, training cohort
- High-risk patients had low monocytic HLA-DR, higher immature neutrophil rates and higher IL10 concentrations
ICU-AI, validation cohort (257 septic patients)
- Significantly higher mortality and longer ICU LOS in high-risk group
Original publication
Identification of a sub-group of critically ill patients with high risk of intensive care unit-acquired infections and poor clinical course using a transcriptomic score. Crit Care. Published 21 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →