Do diabetes and poor control of acute stress-related hyperglycemia increase the risk of ICU-acquired infections? A retrospective assessment in patients with septic shock
Authors' conclusion
72-hour poor glycemic control, but not preexisting diabetes, was independently associated with an increased risk of ICU-acquired infections in septic shock patients and may therefore contribute to the post-aggressive immunosuppressive response.
Study context
- Population
- Patients with septic shock alive in the ICU after 72 h, 2008–202322% preexisting diabetes
- Participants
- 901 patients
- Exposure
- Poor vs adequate glycaemic control in the first 72 h; preexisting diabetes vs none
- ICU-acquired infectionsn = 243
- Outcome
- ICU-acquired infections
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
ICU-acquired infections developed
243
26.9%
Median time from ICU admission to diagnosis (IQR)
9 days
6–13
Observational data: associations, not effects.
Further findings
Mild or severe hyperglycaemia for >20% of time · first 72 h
P = 0.005
Hyperglycaemic episodes > 8 mmol/L prompting fast-acting insulin
- Patients with hyperglycaemic episodes > 8 mmol/L
- 71%
Original publication
Do diabetes and poor control of acute stress-related hyperglycemia increase the risk of ICU-acquired infections? A retrospective assessment in patients with septic shock. Ann Intensive Care. Published 22 October 2025. doi:10.
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