The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections
An erratum to this article was published (Intensive Care Med, Jun 2024 ↗)
Study context
- Population
- ICU patients with hospital-acquired bloodstream infections (HABSI)
- Participants
- 2,209 patients · 201 intensive care units (ICUs) · 47 countries
- Comparison
- Centre/country-based factors and adequate antimicrobial therapy and 28-day mortality
- Primary endpoint
- Associations between centre/country-based factors and two process and outcome indicators: adequacy of antimicrobial therapy within the first 24 h and 28-day mortality
Methodological detailsmultinational, mixed logistic models clustered by centre
- Multinational
- Mixed logistic models clustered by centre
Primary result
As reported in the abstract
- Adequate antimicrobial therapy, overall
- 51% (n = 1128)
- 28-day mortality, overall
- 38% (n = 839)
- Adequate therapy: Therapeutic drug monitoring (TDM) for aminoglycosides everyday, OR
- 1.48 (1.03-2.14) (95% CI)
- Adequate therapy: TDM for aminoglycosides within a few hours, OR
- 1.79 (1.34-2.38) (95% CI)
- Adequate therapy: weekly surveillance cultures for multidrug-resistant organism carriage, OR
- 1.45 (1.09-1.93) (95% CI)
- 28-day mortality: intermediate care beds, OR
- 0.63 (0.47-0.84) (95% CI)
- 28-day mortality: TDM for aminoglycoside available everyday, OR
- 0.66 (0.44-1.00) (95% CI)
- 28-day mortality: TDM for aminoglycoside within a few hours, OR
- 0.51 (0.37-0.70) (95% CI)
- 28-day mortality: 24/7 consultation of clinical pharmacists, OR
- 0.67 (0.47-0.95) (95% CI)
- 28-day mortality: Vancomycin-resistant enterococci (VRE) 10% to 25% in the ICU, OR
- 1.67 (1.00-2.80) (95% CI)
Original publication
The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections. Intensive Care Med. Published 18 March 2024. doi:10.
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