Pediatric anesthesia & critical care
Cryoanalgesia for Pain Management After Pectus Excavatum Repair (COPPER) in Adolescents: A Randomized Controlled Trial
Primary result · PedsQLResult — go to the resultDifference 6.5 95% CI 0.46–13Authors' conclusion
Cryoanalgesia did not improve return to baseline quality of life 2 weeks after surgery. However, it showed to be beneficial in the psychosocial component of the PedsQL scale.
Study context
- Population
- Adolescents undergoing minimally invasive pectus excavatum repair, Istituto Gaslini, Genova, Italy
- Participants
- 88 adolescents
- Comparison
- Cryoanalgesia vs standard of care
- Cryoanalgesian = 45
- Standard of caren = 43reference
- Primary endpoint
- Pediatric Quality of Life (PedsQL) and subcomponents (psychosocial and physical health)
- Follow-up
- 14 days after surgery
Methodological detailsactive controlled, parallel groups, Conducted between February 2022 and October 2023
- Active controlled
- Parallel groups
- Conducted between February 2022 and October 2023
Primary result
PedsQL · 14th day
Difference
6.5
95% CI 0.46–13
P = 0.07
By group
Cryoanalgesia
59.8
median · IQR 48.4–71.2
Standard of care
67.9
median · IQR 58.7–73.9
Standard of care vs Cryoanalgesia
difference 6.5 (95% CI 0.46–13); P = 0.07
As reported in the abstract
Further findings
| Outcome | Standard of care | Difference (95% CI) | P value | |
|---|---|---|---|---|
| PedsQL, per-protocol analysis · 14th dayPP analysis | median 69.02 (IQR 58.70–73.91) | 7.4 (0.82–14) | P = 0.028 | |
| −1001020Difference (linear scale) |
PedsQL subcomponents, decrease within arm
- Psychosocial health: more marked decrease in standard of care arm
- q-value = 0.028
- Psychosocial health: decrease in cryoanalgesia arm not significant
- q-value = 0.056
- Significant decrease in PedsQL total score and subcomponents irrespective of treatment; physical health decreased in both arms
Original publication
Cryoanalgesia for Pain Management After Pectus Excavatum Repair (COPPER) in Adolescents: A Randomized Controlled Trial. Paediatr Anaesth. Published 4 March 2025. doi:10.
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