Perioperative medicine & outcomes
Current evidence of multimodal anesthesia on postoperative outcomes: A systematic review and Meta-analysis
Authors' conclusion
MMA shows no clear effect on postoperative pain at 24 h but reduces PONV incidence and opioid consumption.
Study context
- Population
- Adults undergoing elective surgery
- Participants
- 1,828 adults · 21 RCTs
- Comparison
- MMA vs opioid-based GA
- Outcome
- Postoperative pain, PONV, QoR-15 and pulmonary complications
Methodological detailsRoB 2, GRADE
- RoB 2
- GRADE
Pooled result
As reported in the abstract
MMA vs Opioid-based GAMD (95% CI)
Pain intensity at 24 h; 10 trials, n = 785; very low certainty
−0.6(−1.5 to 0.2)
MMA vs Opioid-based GARelative risk (95% CI)
PONV incidence; 4 trials, n = 352; low certainty
0.59(0.44–0.77)
Further pooled results
| Outcome | MD (mg MME) (95% CI) | |
|---|---|---|
| Opioid consumption · 24 h10 trials, n = 915; moderate certainty | −7.0 (−12.8 to −1.3) | |
| −20−10010Difference, mg MME (linear scale) |
| Outcome | Estimate |
|---|---|
| Opioid consumption · 48 h | MD −14.0 mg MME |
| Opioid consumption · study end | MD −16.0 mg |
PACU LOS
- Data insufficient for pooling
Original publication
Current evidence of multimodal anesthesia on postoperative outcomes: A systematic review and Meta-analysis. J Clin Anesth. Published 12 August 2026. doi:10.
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