Cardiothoracic & vascular anesthesia
Perioperative Multimodal General Anesthesia Focusing on Specific Central Nervous System Targets Does Not Reduce Postoperative Interleukin-6 and Neurofilament Light Levels in Patients Undergoing Cardiac Surgeries: A Randomized Controlled Trial
Authors' conclusion
MMGA did not reduce postoperative IL-6 or NFL levels, nor did it improve neurocognitive outcomes, compared with standard of care.
Study context
- Population
- Adults ≥60 years old undergoing CABG, valve, or combined procedures, single tertiary referral hospital
- Comparison
- EEG-guided multimodal GA vs standard-of-care anaesthesia
- Primary endpoint
- Postoperative changes in IL-6 and NFL
- Follow-up
- Baseline, POD 1 and POD 2
Methodological detailsinvestigator-blinded, single-centre
- Investigator-blinded
- Single-centre
Primary result
As reported in the abstract
IL-6 and NFL levels · any time point
- No significant differences in IL-6 or NFL levels at any time point
Further findings
Burst suppression duration
Delirium incidence and long-term cognitive dysfunction · up to 6 months
- Similar between groups
Burst suppression duration
- Significantly longer in MMGA, particularly during and after CPB in male patients
Original publication
Perioperative Multimodal General Anesthesia Focusing on Specific Central Nervous System Targets Does Not Reduce Postoperative Interleukin-6 and Neurofilament Light Levels in Patients Undergoing Cardiac Surgeries: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 5 November 2025. doi:10.
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