Cardiothoracic & vascular anesthesia
Randomized clinical trial between two sedation protocols during transcatheter aortic valve replacement procedures: Ketamine and Propofol versus Remifentanil and Dexmedetomidine
Authors' conclusion
Both protocols showed a low and comparable incidence of cardiovascular adverse events and postoperative complications such as POD and POCD. KETOFOL protocol appears to offer greater sedative stability and seems to be more protective regarding the incidence of respiratory adverse events.
Study context
- Population
- Patients undergoing procedural sedation for transcatheter aortic valve replacement (TAVR), university hospital198 analysed
- Participants
- 231 patients
- Comparison
- KETOFOL vs Remifentanil and Dexmedetomidine (REMIDEX) sedation during TAVR
Methodological detailsmonocentric, prospective
- Monocentric
- Prospective
Primary result
As reported in the abstract
Sedation efficacy · intraoperative
- Significantly longer induction times with REMIDEX
- More pharmacological adjustments with REMIDEX
Safety
%
| Outcome | KETOFOL | REMIDEX | OR (95 % CI) | |
|---|---|---|---|---|
| Respiratory acidosisMultivariate logistic regression | 54.3 | 67.7 | 1.864 (1.014–3.427) | |
| 0.20.5125Odds ratio (log scale) |
Intraoperative agitation and desaturation
- Higher incidence of intraoperative agitation and more desaturation episodes with REMIDEX
Other intraoperative or postoperative safety indicators
- No other differences observed
Original publication
Randomized clinical trial between two sedation protocols during transcatheter aortic valve replacement procedures: Ketamine and Propofol versus Remifentanil and Dexmedetomidine. J Clin Anesth. Published 27 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →