Cardiothoracic & vascular anesthesia
Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Replacement Using the Transfemoral Approach
Authors' conclusion
Compared with propofol, procedural sedation with dexmedetomidine in TAVR was associated with a significantly lower incidence of delayed neurocognitive recovery.
Study context
- Population
- Patients undergoing transfemoral transcatheter aortic valve replacement (TAVR) under procedural sedation, University Medical Centre Ljubljana, Slovenia, January 2019 to June 202171 analysed
- Participants
- 78 patients
- Comparison
- Procedural sedation with dexmedetomidine vs propofol
- Dexmedetomidinen = 37
- Propofoln = 34reference
Methodological detailsprospective, double-blind, single-centre
- Prospective
- Double-blind
- Single-centre
Primary result
As reported in the abstract
Delayed neurocognitive recovery (MMSE) · 48 hours after TAVR
- Better cognitive outcomes in the dexmedetomidine group (p = 0.022)
- Dexmedetomidine vs Propofol: P = 0.005
Further findings
| Outcome | P value |
|---|---|
| Baseline MMSE scores before TAVRNo statistically significant difference | P = 0.253 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Replacement Using the Transfemoral Approach. J Cardiothorac Vasc Anesth. Published 6 May 2023. doi:10.
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