Cardiothoracic & vascular anesthesia
The Association Between Enhanced Recovery After Cardiac Surgery–Guided Analgesics and Postoperative Delirium
Authors' conclusion
The use of an opioid-sparing perioperative ERACS pain regimen was not associated with reduced postoperative delirium, opioid consumption, or additional poor outcomes. Individually, acetaminophen was associated with reduced delirium.
Study context
- Population
- Adults ≥18 years undergoing elective (nonemergent) coronary, valve, or ascending aorta surgery, Nov 2017–Feb 2021
- Participants
- 1,675 adults
- Exposure
- Enhanced Recovery After Cardiac Surgery (ERACS)-guided multimodal analgesic components vs none
- Outcome
- Postoperative delirium (CAM-ICU, assessed by bedside nurses)
Methodological detailssingle-centre, tertiary academic
- Single-centre
- Tertiary academic
Main finding
As reported in the abstract
Postoperative delirium
Odds ratio (95% CI)
Any component of multimodal regimen
0.85(0.63–1.16)
Acetaminophen
0.60(0.37–0.95)
Gabapentin
1.36(0.97–2.21)
Lidocaine
0.86(0.53–1.37)
Ketamine
1.15(0.72–1.83)
Dexmedetomidine
0.79(0.46–1.31)
- Delirium incidence, all patients
- 220 of 1,675 (13.7%)
Observational data: associations, not effects.
Secondary outcomes
Hospital LOS, intensive care unit (ICU) duration, postoperative opioid administration, postoperative intubation duration
- Individual ERACS elements associated with these secondary outcomes
Original publication
The Association Between Enhanced Recovery After Cardiac Surgery–Guided Analgesics and Postoperative Delirium. J Cardiothorac Vasc Anesth. Published 8 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →