Cystatin C-Guided Dosing Nomogram Improves Target Attainment for Cefepime in the Critically Ill
Authors' conclusion
Use of a cystatin C-inclusive dosing nomogram for cefepime could improve target attainment without increasing the risk of potentially toxic levels in the critically ill.
Study context
- Population
- Critically ill adults treated with cefepime, with baseline cystatin C and follow-up cefepime levels
- Participants
- 120 adults
- Comparison
- eGFR cr-cys-based cefepime dosing nomogram vs administered doses
- Outcome
- 100% ƒT > MIC at 24 hr
- Follow-up
- 24 hours
Methodological detailssingle academic medical center
- Single academic medical center
Main finding
As reported in the abstract
P < 0.001
Further findings
Median ƒAUC 0-24
P = 0.01
Safety
ƒAUC 0-24 too high (> 900) or too low (< 300)
P = 0.004
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cystatin C-Guided Dosing Nomogram Improves Target Attainment for Cefepime in the Critically Ill. Crit Care Med. Published 27 February 2025. doi:10.
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