Higher doses of fluconazole are needed to ensure target attainment in critically ill adults on continuous Veno-venous hemodialysis
Authors' conclusion
According to the results of the study, increasing the fluconazole dose to at least 400 mg twice daily is sufficient to reach the desired target in critically ill patients undergoing CVVHD.
Study context
- Population
- Critically ill adults undergoing continuous veno-venous hemodialysis (CVVHD)
- Exposure
- Higher vs standard doses of intravenous fluconazole
- Outcome
- Fluconazole target attainment
Main finding
As reported in the abstract
Target attainment
Higher doses
100 %
- Only fluconazole dose significantly influenced target attainment; no other predefined factor had a significant impact
- P < 0.001
Observational data: associations, not effects.
Original publication
Higher doses of fluconazole are needed to ensure target attainment in critically ill adults on continuous Veno-venous hemodialysis. J Crit Care. Published 26 September 2024. doi:10.
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