Impact of fluid removal rate on patients receiving continuous renal replacement therapy for acute kidney injury
Authors' conclusion
In a large single center cohort, low fluid removal rate was an independent risk factor for 90-day mortality. High fluid removal rates may improve, but certainly do not worsen, outcomes.
Study context
- Population
- Adults admitted to ICU at the University of Chicago with acute kidney injury (AKI) treated with continuous veno-venous hemodialysis (CVVHD), April 2016–March 2020
- Participants
- 1,242 adults
- Exposure
- Low or high vs intermediate fluid removal rate during CVVHD
- Outcome
- 90-day mortality
- Follow-up
- 90 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Low fluid removal rate
74 %
Adjusted hazard ratio (CI)
Low fluid removal rateadjusted hazards model; significant
2.74(1.58–4.76)
High fluid removal rateadjusted hazards model; not significant
0.50(0.30–1.03)
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Significant differences between groups in congestive HF, baseline weight and cumulative fluid balance before CVVHD
Original publication
Impact of fluid removal rate on patients receiving continuous renal replacement therapy for acute kidney injury. J Crit Care. Published 30 June 2025. doi:10.
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