Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation
Authors' conclusion
Critically ill patients with severe SARS-CoV-2 related ARDS requiring vv-ECMO are at high risk of early acute kidney injury.
Study context
- Population
- Critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation (vv-ECMO), University Medical Center Hamburg-Eppendorf (Germany), March 2020–July 2021
- Participants
- 91 patients
- Exposure
- RRT vs no RRT
- Early-AKIn = 41
- Late-AKIn = 35
- No acute kidney injury (AKI)n = 15reference
- Outcome
- Incidence of AKI and progression to RRT
- Follow-up
- ICU stay
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AKI during ICU stay
- RRT required during ICU stay, overall
- 70% (n = 64)
- RRT required, early-AKI
- 93%
- RRT required, late-AKI
- 74%
Observational data: associations, not effects.
Further findings
Risk factors for early-AKI
| OR (95% CI) | P value | ||
|---|---|---|---|
| Younger age | 0.94 (0.90–0.99) | P = 0.02 | |
| SAPS II | 1.12 (1.06–1.19) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
SAPS II on admission, RRT vs no RRT
P < 0.05
SOFA score on admission, RRT vs no RRT
P < 0.05
ICU LOS, RRT vs no RRT
P = 0.27
ICU mortality, RRT vs no RRT
P = 0.23
Original publication
Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation. Ann Intensive Care. Published 24 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →