Cytomegalovirus infection in intensive care unit patients with hematological malignancies: Characteristics and clinical outcomes
Authors' conclusion
In critically-ill hematological patients, CMV viral load is independently associated with hospital mortality.
Study context
- Population
- Adult ICU patients with underlying hematological malignancy and cytomegalovirus (CMV) infection, Jan 2010-Dec 2017
- Participants
- 178 patients
- Outcome
- Hospital mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hospital mortality
53%
n = 95
Need for vasopressors associated with hospital mortality (aOR)
OR 2.53; 95%CI 1.11-5.97
Viral load associated with hospital mortality (aOR per Log)
OR 1.88 per Log; 95%CI 1.29-2.85
Observational data: associations, not effects.
Further findings
CMV disease
- CMV disease
- 44 (24.7%)
- Allogeneic stem cell transplantation associated with CMV disease
- OR 2.55; 95%CI 1.05-6.16
- Mechanical ventilation associated with CMV disease
- OR 4.11; OR 1.77-10.54
- Viral load associated with CMV disease (per Log)
- OR 1.77 per Log; 95%CI 1.23-2.61
- Coinfections not associated with CMV disease
- Independently associated
Viral load and coinfections
- Median viral load
- 2.7 Log [2.3-3.5]
- Coinfections
- 159 patients (89.3%)
Original publication
Cytomegalovirus infection in intensive care unit patients with hematological malignancies: Characteristics and clinical outcomes. J Crit Care. Published 12 March 2024. doi:10.
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