Daptomycin is associated with higher treatment failure rates than alternatives for Enterococcus faecium bloodstream infections in critically ill patients: a multicentric retrospective cohort
Main finding · Treatment failureResult — go to the resultAdjusted subdistribution hazard ratio 2.53 CI 1.14–5.62Authors' conclusion
In this multicenter retrospective cohort of critically ill patients with monomicrobial E. faecium bloodstream infections, use of daptomycin as the definitive antibiotic regimen was associated with a higher rate of treatment failure.
Study context
- Population
- Adults with monomicrobial E. faecium bloodstream infection during intensive care unit (ICU) stay, 11 ICUs of Paris University hospitals, 2017–2022
- Participants
- 166 adults
- Exposure
- Daptomycin vs other antibiotics as definitive regimen
- Daptomycinn = 26
- Non-daptomycinn = 140reference
- Outcome
- Composite treatment failure: prolonged bacteremia (≥3days) under treatment and/or relapse within 30 days after end of treatment and/or need for salvage therapy within 30 days
Methodological detailsmulticentre, competing-risks models, propensity score-based analyses
- Multicentre
- Competing-risks models
- Propensity score-based analyses
Main finding
Treatment failure
Adjusted subdistribution hazard ratio
2.53
CI 1.14–5.62
P = 0.022
Daptomycin vs Non-daptomycin
aSHR 2.53 (CI 1.14–5.62); P = 0.022
As reported in the abstract
Observational data: associations, not effects.
Further findings
Treatment failure, vancomycin-only comparators (sensitivity analysis)
- Daptomycin vs vancomycin, aSHR
- aSHR 2.26 [1.00-5.10], p=0.051
- Yielded similar results
Time to adequate antibiotic regimen
- Not different between groups (days)
- 1 [0-2] vs 1 [0-2] days, p=0.22
Source control
- Not different between groups
- 63% vs 43%, p=0.17
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Daptomycin is associated with higher treatment failure rates than alternatives for Enterococcus faecium bloodstream infections in critically ill patients: a multicentric retrospective cohort. Crit Care. Published 27 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →