Bloodstream infections among patients receiving therapeutic plasma exchanges in the intensive care unit: a 10 year multicentric study
Authors' conclusion
Blood stream infections are frequent in patients receiving TPE in the ICU, and are associated with a severe ICU course.
Study context
- Population
- ICU patients receiving ≥1 session of therapeutic plasma exchange (therapeutic plasma exchanges (TPE)), 4 ICUs in Paris, France, 2010–2019
- Participants
- 387 patients · 4 ICUs
- Exposure
- Patients with blood stream infection (BSI) vs without BSI during ICU stay
- BSIn = 31
- Outcome
- BSI incidence
- Follow-up
- During ICU stay
Methodological detailsmulticentre, Median 5 [2-7] TPE sessions per patient
- Multicentre
- Median 5 [2-7] TPE sessions per patient
Main finding
As reported in the abstract
BSI during ICU stay
BSI
8%
31
- Median time to BSI after start of TPE, days [IQR]
- 7 [3-11]
Observational data: associations, not effects.
Further findings
Independent risk factors for BSI (multivariate logistic regression)
| OR (CI) | ||
|---|---|---|
| Diabetes | 3.32 (1.21–8.32) | |
| Total number of TPE sessions | 1.14 (1.08–1.20) | |
| 0.10.31310Odds ratio (log scale) |
Mechanical ventilation
P = 0.001
RRT
P = 0.011
Vasopressors
P = 0.004
Mortality
P = 0.010
- TPE catheter-related BSI vs other sources: catheter insertion site and catheter-related DVT — No difference in catheter insertion site
- p = 0.458
- TPE catheter-related BSI vs other sources: catheter insertion site and catheter-related DVT — No difference in TPE catheter related DVT
- p = 0.601
- TPE catheter-related BSI vs other sources: catheter insertion site and catheter-related DVT: TPE catheter infection related BSI 35%
- TPE catheter-related BSI vs other sources: catheter insertion site and catheter-related DVT: Other sources of BSI 65%
Original publication
Bloodstream infections among patients receiving therapeutic plasma exchanges in the intensive care unit: a 10 year multicentric study. Ann Intensive Care. Published 29 July 2024. doi:10.
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