Respiratory failure & ventilation
Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*
Authors' conclusion
Dead-space ventilation indices were independently associated with mortality in adults with ARDS.
Study context
- Population
- Adults with acute respiratory distress syndrome (ARDS) reporting a dead-space ventilation index and mortality28 studies
- Comparison
- High vs low dead-space ventilation indices
- Outcome
- Mortality
Methodological detailsrandom effects model, QUIPS risk of bias, GRADE
- Random effects model
- QUIPS risk of bias
- GRADE
Pooled result
As reported in the abstract
Odds ratio (95% CI)P value
High pulmonary dead-space fractionI2 = 84%
3.52(2.22–5.58)
P < 0.001Every 0.05 increase in pulmonary dead-space fractionadjusted; I2 = 57%
1.23(1.13–1.34)
P < 0.001High ventilatory ratioI2 = 48%
1.55(1.33–1.80)
P < 0.001High ventilatory ratioadjusted; I2 = 66%
1.33(1.12–1.58)
P = 0.001Every 0.05 increase in pulmonary dead-space fraction, as printed
Original publication
Dead-Space Ventilation Indices and Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*. Crit Care Med. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →