Respiratory failure & ventilation
Mechanical power normalisation methods to predict ICU mortality: a retrospective cohort study
Authors' conclusion
Mechanical power normalised to compliance and MPratio had better discrimination for ICU mortality than MP, although the difference was modest and absolute predictive power remained limited.
Study context
- Population
- Mechanically ventilated adults in a single centre over a seven-year period
- Participants
- 3,578 participants
- Exposure
- Mechanical power (MP) normalised to dead space, compliance or as MPratio vs MP without normalisation
- Outcome
- Discriminatory accuracy (AUROC) for ICU mortality
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
ICU mortality discrimination (AUROC)
MP/compliance
0.71
AUROC · 95% CI 0.69–0.73
MPratio
0.71
AUROC · 95% CI 0.68–0.73
MP
0.69
AUROC · 95% CI 0.66–0.71
MP/compliance vs MP: P = 0.007 · MPratio vs MP: P = 0.0014
Observational data: associations, not effects.
Further findings
Linearity of MP and MPratio relationship with ICU mortality
- Statistically significant but small departure from linearity
Original publication
Mechanical power normalisation methods to predict ICU mortality: a retrospective cohort study. Ann Intensive Care. Published 30 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →