Death and new disability following bleeding complications during venoarterial extracorporeal membrane oxygenation. A prospective cohort study from the EXCEL registry
Main findingResult — go to the resultRD 8.95 % 95 % CI 1.62–16.14Authors' conclusion
Bleeding increased the rate of death and disability at 6-months, but this was driven by increased disability rather mortality. Bleeding complications were associated with an increased use of healthcare resources.
Study context
- Population
- Patients on VA ECMO enrolled in the EXCEL registry, February 2019 to June 2023
- Participants
- 704 patients
- Exposure
- Bleeding complications vs no bleeding during VA ECMO
- Bleedingn = 312
- Outcome
- Composite of:
- Death
- New disability (increase of ≥10% in WHO disability assessment schedule score)
- Follow-up
- 180 days after ECMO initiation
Methodological detailsmulticentre, prospective observational, registry (EXCEL), multivariable logistic and quantile regression
- Multicentre
- Prospective observational
- Registry (EXCEL)
- Multivariable logistic and quantile regression
Main finding
As reported in the abstract
6 months
Risk difference (RD)
8.95 %
95 % CI 1.62–16.14
Bleeding vs No bleeding
RD 8.95 % (95 % CI 1.62–16.14)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted RD (95 % CI) | |
|---|---|---|
| New disability | 18.04 % (6.22–29.55) | |
| Mortality | 5.71 % (−1.55 to 13.01) | |
| −2002040Difference (linear scale) |
VA ECMO for peri-operative support
P < 0.001
Major bleeding
- Major bleeding
- 154 (22.3 %)
Healthcare resource use (ICU LOS, RRT)
- Bleeding associated with increased use of healthcare resources such as ICU LOS and RRT
Original publication
Death and new disability following bleeding complications during venoarterial extracorporeal membrane oxygenation. A prospective cohort study from the EXCEL registry. J Crit Care. Published 15 October 2025. doi:10.
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