Sex differences in venoarterial extracorporeal membrane oxygenation utilisation and clinical outcomes in Australia
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.41 95% CI 1.07–1.87Authors' conclusion
Despite younger age and fewer traditional risk factors, female sex is associated with increased adjusted risk of in-hospital mortality and bleeding in VA-ECMO patients.
Study context
- Population
- Adults supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO) in Australia, EXCEL registry, February 2019 to December 2024
- Participants
- 1,443 adults
- Exposure
- Female vs male sex
- Outcome
- In-hospital mortality
Methodological detailsbinational registry, multivariable logistic regression
- Binational registry
- Multivariable logistic regression
Main finding
As reported in the abstract
Odds ratio
1.41
95% CI 1.07–1.87
P = 0.015
Female vs Male
OR 1.41 (95% CI 1.07–1.87); P = 0.015
Observational data: associations, not effects.
Further findings
Sex distribution
Sex distribution
- Females younger, lower APACHE IV scores, more often ECMO for myocarditis, PE and advanced pulmonary hypertension; males more often acute MI and cardiac arrest with shockable rhythm
Safety
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Major bleedingAdjusted | 1.40 (1.03–1.91) | P = 0.033 | |
| 0.512Odds ratio (log scale) |
Original publication
Sex differences in venoarterial extracorporeal membrane oxygenation utilisation and clinical outcomes in Australia. J Crit Care. Published 29 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →