Decreased incidence of acute kidney injury following donation after circulatory death orthotopic liver transplantation using normothermic machine perfusion
Main findingResult — go to the resultRelative risk 0.64 95% CI 0.44–0.93Authors' conclusion
NMP was associated with a reduced incidence of postoperative AKI in DCD liver transplantation.
Study context
- Population
- Adult recipients of DCD liver transplants, January 2021 through December 2022
- Participants
- 195 recipients
- Exposure
- Normothermic machine perfusion (NMP) vs static cold storage (SCS) allografts
- NMPn = 95
- SCSn = 100reference
- Outcome
- Postoperative AKI (Kidney Disease: Improving Global Outcomes criteria)
Methodological detailssingle-center, inverse probability weighting
- Single-center
- Inverse probability weighting
Main finding
As reported in the abstract
Relative risk
0.64
95% CI 0.44–0.93
P = 0.02
NMP vs SCS
RR 0.64 (95% CI 0.44–0.93); P = 0.02
- Acute kidney injury (AKI) overall
- 38.5%
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Postreperfusion syndrome | 0.29 (0.16–0.53) | P < 0.001 | |
| Early allograft dysfunction | 0.57 (0.42–0.77) | P < 0.001 | |
| 0.10.31310Relative risk (log scale) |
Median
| Outcome | NMP | SCS | P value |
|---|---|---|---|
| Blood transfusions | 10.0 | 20.0 | P < 0.001 |
Safety
RRT, hemodialysis at discharge, CKD at 90 days
- No differences observed
Original publication
Decreased incidence of acute kidney injury following donation after circulatory death orthotopic liver transplantation using normothermic machine perfusion. J Clin Anesth. Published 27 April 2026. doi:10.
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