Respiratory failure & ventilation
Definition and Clinical Evaluation for Trimethoprim-Sulfamethoxazole Severe Acute Respiratory Failure
Authors' conclusion
TMP-SMX is a commonly prescribed antibiotic. However, we find it imperative to share this relatively rare but life-threatening condition with clinicians as the mortality rate approaches 40%.
Study context
- Population
- Previously healthy young patients (10–37) with trimethoprim-sulfamethoxazole (TMP-SMX)-associated severe respiratory failure, no preexisting pulmonary disease, other cause or chronic smoking/vaping; US ICUs, 1996–2021
- Participants
- 19 patients
- Outcome
- Clinical characteristics, genetics and pathology of TMP-SMX severe respiratory failure
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Carriers of both HLA-B*07:02 and HLA-C*07:02 alleles among available genomic data (n = 11)
100%
Observational data: associations, not effects.
Further findings
- Mortality rate approaches 40%
Original publication
Definition and Clinical Evaluation for Trimethoprim-Sulfamethoxazole Severe Acute Respiratory Failure. Crit Care Med. Published 14 July 2023. doi:10.
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