ICU sedation, delirium & recovery
Definitions and Prognoses of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome: A Comparative Analysis via Systematic Review and Observational Study in Japan
Authors' conclusion
The present study revealed marked heterogeneity among existing PICS definitions, resulting in wide variations in prevalence and outcomes. Despite this variability, PICS consistently identified patients with prolonged hospitalization and physical impairment.
Study context
- Population
- Critically ill adults admitted to ICUs in Japan, March 2010–September 2021 (Medical Data Vision database)23 studies reviewed
- Participants
- 215,474 adults
- Comparison
- Heterogeneous PICS definitions applied to the same ICU cohort
- Outcome
- PICS identification by definition
Methodological detailsmulticentre, administrative claims database
- Multicentre
- Administrative claims database
Pooled result
As reported in the abstract
Patients meeting each definition
211-47,888
PICS prevalence across definitions (range)
0.1-22.2%
Further pooled results
In-hospital mortality across definitions
- Range
- 11.4-64.0%
Discharge Barthel Index <90 across definitions
- Range
- 46.5-78.9%
Hospital LOS >28 days across definitions
- Range
- 54.9-94.7%
Original publication
Definitions and Prognoses of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome: A Comparative Analysis via Systematic Review and Observational Study in Japan. Crit Care Med. Published 3 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →