ICU sedation, delirium & recovery
Delirium During Critical Illness and Subsequent Change of Treatment in Patients With Cancer: A Mediation Analysis*
Main finding · Change in cancer treatment after dischargeResult — go to the resultAdjusted odds ratio 3.80 95% CI 2.72–5.35Authors' conclusion
Patients who had delirium during ICU stay had a higher rate of modification of cancer treatment after discharge. The effect of delirium on change in cancer treatment was only partially mediated by the development of functional dependence after discharge. Change in cancer treatment was associated with increased 1-year mortality.
Study context
- Population
- Adults ≥18 years with a previous proposal of cancer treatment admitted to a 50-bed ICU in a dedicated cancer center
- Participants
- 1,134 adults
- Exposure
- Delirium vs no delirium during ICU stay
- Deliriumn = 189
- Outcome
- Change in cancer treatment after discharge
Methodological detailsmediation analysis, single-centre
- Mediation analysis
- Single-centre
Main finding
As reported in the abstract
Adjusted odds ratio
3.80
95% CI 2.72–5.35
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Mortality with change in treatment vs no change · 1 year | 2.68 (2.01–3.60) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Proportion of delirium effect on change of treatment mediated by functional dependence after discharge (mediation analysis)
- Proportion mediated
- 33.0% (95% CI, 21.7-46.0%)
- Association both direct and mediated by functional dependence after discharge
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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