ICU sedation, delirium & recovery
Delirium in ventilated patients receiving fentanyl and morphine for Analgosedation: Findings from the ANALGESIC trial
Authors' conclusion
Fentanyl is associated with a higher incidence of hospital inpatient delirium when used for analgosedation compared with morphine, and the dose of opioid is linearly related to the need for antipsychotic medication administration.
Study context
- Population
- Patients receiving mechanical ventilation in the ANALGESIC trial
- Participants
- 681 patients
- Comparison
- Fentanyl vs morphine for analgosedation
- Fentanyln = 344
- Morphinen = 337reference
- Primary endpoint
- Hospital inpatient delirium (coding diagnosis of delirium)
Methodological detailscluster randomized, cluster crossover
- Cluster randomized
- Cluster crossover
Primary result
As reported in the abstract
Each group vs morphineAbsolute difference, % (95% CI)
Fentanyl
7.34(−0.9 to 14.78)
Each group vs morphineRelative risk (95% CI)P value
Fentanyl
1.19(1.00–1.41)
P = 0.053Further findings
Antipsychotic use and opioid dose
- Antipsychotic use linearly related to opioid dose
Antipsychotic use and mortality
- Antipsychotic use not associated with increased mortality
Original publication
Delirium in ventilated patients receiving fentanyl and morphine for Analgosedation: Findings from the ANALGESIC trial. J Crit Care. Published 24 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →