ICU sedation, delirium & recovery
Ketamine-based intensive care unit (ICU) sedation and patient-centered outcomes: A systematic review and meta-analysis of mechanical ventilation duration, ICU length of stay, and delirium
Study context
- Population
- Adult ICU patients
- Participants
- 903 patients · 6 studies
- Comparison
- IV ketamine-based sedation vs standard analgosedation
- Outcome
- Mechanical ventilation duration (MVD), ICU length of stay (LOS) and delirium incidence
Methodological detailsPRISMA, random-effects models
- PRISMA
- Random-effects models
Pooled result
As reported in the abstract
MVD, ICU LOS and delirium incidence
Ketamine vs Standard sedationMD (95% CI)
MVD (6 studies); not statistically significant
−0.30(−1.53 to 0.92)
ICU LOS (5 studies); significant reduction
−0.86(−1.51 to −0.22)
Ketamine vs Standard sedationOdds ratio (95% CI)
Delirium incidence (2 studies); significant decrease
0.55(0.43–0.72)
Original publication
Ketamine-based ICU sedation and patient-centered outcomes: A systematic review and meta-analysis of mechanical ventilation duration, ICU length of stay, and delirium. J Crit Care. Published 24 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →