ICU sedation, delirium & recovery

Pre-ICU hospital length of stay and 30-day mortality in the very old: a national cohort of 315 042 ICU admissions

Ann Intensive CarePublished Retrospective cohort study

Authors' conclusion

Pre-ICU hospital length of stay is a weaker prognostic marker in VIPs than in the majority of ICU patients, although the extent to which this reflects biology versus age-dependent ICU triage remains unresolved.

Study context

Population
All adult first ICU admissions, Swedish Intensive Care Registry 2005–2016
Participants
315,042 admissions
Exposure
Association of pre-ICU LOS with 30-day mortality, modified by age
Outcome
30-day mortality by pre-ICU LOS, modified by age
Follow-up
30 days
Methodological detailsnational registry, restricted cubic splines, multiple imputation sensitivity analysis
  • National registry
  • Restricted cubic splines
  • Multiple imputation sensitivity analysis

Main finding

As reported in the abstract

Within-age RD in 30-day mortality, pre-ICU LOS day 0 to day 60
GroupValueday-0 baseline mortality
VIPs12.8 (95% CI 10.0–15.6) percentage points34.6 %
60-69-year-olds17.5 (95% CI 16.0–18.9)

Value

VIPs12.8 (95% CI 10.0–15.6) percentage points
60-69-year-olds17.5 (95% CI 16.0–18.9)

day-0 baseline mortality

VIPs34.6 %
60-69-year-olds— not stated in the abstract

Observational data: associations, not effects.

Further findings

Sensitivity analyses (Simplified Acute Physiology Score (SAPS3) functional form; adjustment for acute physiology with multiple imputation)

Findings consistent across sensitivity analyses

Original publication

Pre-ICU hospital length of stay and 30-day mortality in the very old: a national cohort of 315 042 ICU admissions. Ann Intensive Care. Published 16 July 2026. doi:10.1016/j.aicoj.2026.100116

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