ICU sedation, delirium & recovery
Depression or anxiety and long-term mortality among adult survivors of intensive care unit: a population-based cohort study
Authors' conclusion
ICU survivors newly diagnosed with depression or anxiety exhibit higher long-term mortality rates compared to those without such diagnoses, including those diagnosed before ICU admission. Particularly, newly diagnosed depression is associated with an elevated mortality rate.
Study context
- Population
- Adults admitted to the intensive care unit (ICU) 2015–2019 for medical reasons who survived at least 1 year after ICU discharge, no ICU stay in previous 2 years
- Participants
- 799,645 adults
- Exposure
- ICU survivors with vs without depression or anxiety diagnosis
- Newly diagnosed with depression or anxietyn = 98,530
- Prior diagnosesn = 265,092
- Outcome
- Long-term cumulative mortality
- Follow-up
- Up to 7 years
Methodological detailsmultivariate Cox proportional hazards regression
- Multivariate Cox proportional hazards regression
Main finding
As reported in the abstract
Long-term mortality
Adjusted hazard ratio (95% CI)
Newly diagnosed depression or anxiety vs Without depression or anxiety
1.17(1.16–1.19)
Newly diagnosed depression alone vs Without depression or anxiety
1.28(1.26–1.30)
Newly diagnosed anxiety alone vs Without depression or anxiety
1.08(1.06–1.11)
Prior diagnosis vs Without depression or anxietyoverall
1.08(1.07–1.09)
Prior depression vs Without depression or anxiety
1.12(1.11–1.14)
Prior anxiety vs Without depression or anxiety
1.04(1.03–1.05)
Observational data: associations, not effects.
Original publication
Depression or anxiety and long-term mortality among adult survivors of intensive care unit: a population-based cohort study. Crit Care. Published 6 May 2025. doi:10.
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