Hemodynamics, fluids & transfusion
Desmopressin to reduce periprocedural bleeding and transfusion: a systematic review and meta-analysis
Pooled result · RBC transfusionResult — go to the resultRelative risk 0.95 95% CI 0.86–1.05Authors' conclusion
In conclusion, desmopressin likely reduces periprocedural blood loss and the number of units of blood transfused in small trials with methodologic limitations.
Study context
- Population
- Patients without known inherited bleeding disorders undergoing surgery or other invasive procedures (38 trials cardiac surgery, 22 noncardiac surgery, 3 non-surgical procedures)
- Participants
- 4,163 patients · 63 RCTs
- Comparison
- Peri-procedural desmopressin vs placebo or usual care
- Outcome
- RBC transfusion
Methodological detailsLiterature up to February 1, 2023
- Literature up to February 1, 2023
Pooled result
As reported in the abstract
Relative risk
0.95
95% CI 0.86–1.05
Desmopressin vs Placebo or usual care
RR 0.95 (95% CI 0.86–1.05)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Reoperation due to bleeding22 trials · may not reduce risk | 0.75 (0.47–1.19) | |
| Bleeding events2 trials · certainty of evidence generally low | 0.45 (0.24–0.84) | |
| Transfusion risk, desmopressin vs TXA3 trials; favoring TXA · limited evidence | 2.38 (1.06–5.39) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | MD (mL) (95% CI) | |
|---|---|---|
| Total volume of blood loss, desmopressin vs TXA3 trials; favoring TXA · limited evidence | 391.7 (- 93.3 to 876.7) | |
| −50005001000Difference, mL (linear scale) |
| Outcome | Estimate |
|---|---|
| Number of units of RBC transfused25 trials · certainty of evidence generally low | MD −0.55 units (95% CI - 0.94 to - 0.15) |
| Total volume of blood loss33 trials · certainty of evidence generally low | SMD - 0.40 standard deviations (95% CI - 0.56 to - 0.23) |
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Clinically significant hypotension requiring intervention19 trials | 2.15 (1.36–3.41) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Desmopressin to reduce periprocedural bleeding and transfusion: a systematic review and meta-analysis. Perioper Med (Lond). Published 23 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →