Cardiothoracic & vascular anesthesia
Use of coagulation factor concentrates and blood transfusion in cardiac surgery: a retrospective cohort study of adults with hereditary and acquired bleeding disorders
Authors' conclusion
Acquired bleeding disorders in cardiac surgery patients are associated with increased use of haemostatic interventions, postoperative complications, and increased healthcare costs.
Study context
- Population
- Adult cardiac surgical patients with or without hereditary or acquired bleeding disorders
- Exposure
- Hereditary or acquired bleeding disorders vs no bleeding disorders
- Outcome
- Use of coagulation factor concentrates and blood products
Methodological detailsPremier Health Database
- Premier Health Database
Main finding
As reported in the abstract
| Group | Value | Factor VIIa | Prothrombin complex concentrate |
|---|---|---|---|
| Acquired bleeding disorders | 24% | 24% | 11.7% |
Acquired bleeding disorders
Value24%
Factor VIIa24%
Prothrombin complex concentrate11.7%
Observational data: associations, not effects.
Further findings
- Mortality — Acquired bleeding disorders
- 19.2%
- Mortality — Highest mortality rate in acquired bleeding disorders
- 19.2%
ICU and hospital LOS
- Longer ICU and hospital stays in acquired bleeding disorders
Costs
- Increased factor VIII and IX replacement in hereditary bleeding disorders increased pharmacy costs but did not significantly impact blood bank charges
Safety
| Outcome | Acquired bleeding disorders |
|---|---|
| Haemorrhage and thromboembolic events | |
| Haemorrhage | 15.8% |
| Thromboembolic events | 19.2% |
Haemorrhage and thromboembolic events
- Significantly higher complication rates in acquired bleeding disorders
Original publication
Use of coagulation factor concentrates and blood transfusion in cardiac surgery: a retrospective cohort study of adults with hereditary and acquired bleeding disorders. Br J Anaesth. Published 18 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →